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1

Cellular and biochemical characterization of VX-710 as a chemosensitizer

Germann, Ursula A, Shlyakhter, Dlna, Mason, Valerie S, Zelle, Robert E, Duffy, John P, Galullo, Vincent, Armistead, David M, Saunders, Jeffrey O, Boger, Joshua, Harding, Matthew W

Journal:

Anti-Cancer Drugs

Année:

1997

Fichier:

PDF, 1.23 MB

1997

2

Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-associated protein MRP

Germann, Ursula A, Ford, Pamella J, Shlyakhter, Dina, Mason, Valerie S, Harding, Matthew W

Journal:

Anti-Cancer Drugs

Année:

1997

Fichier:

PDF, 1.21 MB

1997

3

ChemInform Abstract: Inhibitors of p38 MAP Kinase: Therapeutic Intervention in Cytokine-Mediated Diseases

Francesco G. Salituro, Ursula A. Germann, Keith P. Wilson, Guy W. Bemis, Ted Fox, Michael S.-S. Su

Journal:

Année:

1999

Fichier:

PDF, 27 KB

1999

4

Putative “MDR enhancer” is located on human chromosome 20 and not linked to the MDRI gene on chromosome 7

Ursula A. Germann, Patricia V. Schoenlein, Drazen B. Zimonjic, Nicholas C. Popescu, Ira Pastan, Michael M. Gottesman

Journal:

Genes, Chromosomes and Cancer

Année:

1994

Langue:

english

Fichier:

PDF, 747 KB

english, 1994

5

Characterization by somatic cell genetics of a monoclonal antibody to the MDR1 gene product (P-glycoprotein): Determination of p-glycoprotein expression in multi-drug-resistant kb and cem cell variants

Cristina Cenciarelli, Stephen J. Currier, Mark C. Willingham, Franz Thiebaut, Ursula A. Germann, Angelina V. Rutherford, Michael M. Gottesman, Stefano Barca, Marina Tombesi, Stefania Morrone, Angela S

Journal:

International Journal of Cancer

Année:

1991

Langue:

english

Fichier:

PDF, 1.30 MB

english, 1991

6

A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase

Ted Fox, Joyce T. Coll, Xiaoling Xie, Pamella J. Ford, Ursula A. Germann, Margaret D. Porter, S. Pazhanisamy, Mark A. Fleming, Vincent Galullo, Michael S. S. Su, Keith P. Wilson

Journal:

Protein Science

Année:

1998

Langue:

english

Fichier:

PDF, 3.31 MB

english, 1998

7

Regulation of laccase synthesis in inducedNeurospora crassacultures

R. Michael Linden, Boris C. Schilling, Ursula A. Germann, Konrad Lerch

Journal:

Current Genetics

Année:

1991

Langue:

english

Fichier:

PDF, 1.13 MB

english, 1991

8

Molecular analysis of the multidrug transporter

Ursula A. Germann

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 2.90 MB

english, 1993

9

Effects of phosphorylation of P-glycoprotein on multidrug resistance

Ursula A. Germann, Timothy C. Chambers, Suresh V. Ambudkar, Ira Pastan, Michael M. Gottesman

Journal:

Journal of Bioenergetics and Biomembranes

Année:

1995

Langue:

english

Fichier:

PDF, 850 KB

english, 1995

10

Heterologous expression systems for P-glycoprotein:E. coli, yeast, and baculovirus

Gregory L. Evans, Baofu Ni, Christine A. Hrycyna, David Chen, Suresh V. Ambudkar, Ira Pastan, Ursula A. Germann, Michael M. Gottesman

Journal:

Journal of Bioenergetics and Biomembranes

Année:

1995

Langue:

english

Fichier:

PDF, 919 KB

english, 1995

11

Molecular analysis of the multidrug transporter, P-glycoprotein

Ursula A. Germann, Timothy C. Chambers

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 229 KB

english, 1998

12

Detection of recombinant P-glycoprotein in multidrug resistant cultured cells

Ursula A. Germann

Journal:

Molecular Biotechnology

Année:

2000

Langue:

english

Fichier:

PDF, 159 KB

english, 2000

13

Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control

Aronov, Alex M., Tang, Qing, Martinez-Botella, Gabriel, Bemis, Guy W., Cao, Jingrong, Chen, Guanjing, Ewing, Nigel P., Ford, Pamella J., Germann, Ursula A., Green, Jeremy

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 42 KB

english, 2009

14

P-glycoproteins: mediators of multidrug resistance

Ursula A. Germann, Ira Pastan, Michael M. Gottesman

Journal:

Seminars in Cell Biology

Année:

1993

Fichier:

PDF, 795 KB

1993

15

Regulation of inosine monophosphate dehydrogenase type I and type II isoforms in human lymphocytes

Jugnu Jain, Susan J. Almquist, Pamella J. Ford, Dina Shlyakhter, Yongping Wang, Elmar Nimmesgern, Ursula A. Germann

Journal:

Biochemical Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 542 KB

english, 2004

16

Analyzing radiotelemetry data with a mixed model statistical analysis

Donald Bartholomew Hodges Jr., Tao Song, Doris Damian, Ursula A. Germann

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2011

Langue:

english

Fichier:

PDF, 59 KB

english, 2011

17

Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter

Shigeo Tanaka, Stephen J. Currier, Edward P. Bruggemann, Kazumitsu Ueda, Ursula A. Germann, Ira Pastan, Michael M. Gottesman

Journal:

Biochemical and Biophysical Research Communications

Année:

1990

Langue:

english

Fichier:

PDF, 2.25 MB

english, 1990

18

Individual risk assessment in bladder cancer patients based on a multi-marker panel

Tilman Todenhöfer, Jörg Hennenlotter, Stefan Aufderklamm, Ursula Kühs, Georgios Gakis, Miriam Germann, Arnulf Stenzl, Christian Schwentner

Journal:

Journal of Cancer Research and Clinical Oncology

Année:

2013

Langue:

english

Fichier:

PDF, 254 KB

english, 2013

19

Gene Transfer of Drug Resistance Genes Implications for Cancer Therapy

MICHAEL M. GOTTESMAN, URSULA A. GERMANN, IVAN AKSENTIJEVICH, YOSHIKAZU SUGIMOTO, CAROL O. CARDARELLI, IRA PASTAN

Journal:

Annals of the New York Academy of Sciences

Année:

1994

Langue:

english

Fichier:

PDF, 1.13 MB

english, 1994

20

Both ATP Sites of Human P-Glycoprotein Are Essential but Not Symmetric †

Hrycyna, Christine A., Ramachandra, Muralidhara, Germann, Ursula A., Cheng, Priscilla Wu, Pastan, Ira, Gottesman, Michael M.

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 251 KB

english, 1999

21

Structural Flexibility of the Linker Region of Human P-Glycoprotein Permits ATP Hydrolysis and Drug Transport †

Hrycyna, Christine A., Airan, Lisa E., Germann, Ursula A., Ambudkar, Suresh V., Pastan, Ira, Gottesman, Michael M.

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 220 KB

english, 1998

22

Rat spontaneous motor activity, a sensitive first-tier screen of CNS safety for early-drug discovery

Hodges, Donald, Germann, Ursula

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2013

Langue:

english

Fichier:

PDF, 55 KB

english, 2013

23

COPPERED GREEN PEAS.

Hodges, Donald, Germann, Ursula

Journal:

Année:

1892

Langue:

english

Fichier:

PDF, 435 KB

english, 1892

24

High-Throughput Optical Assays for Assessing Drug-Induced Q-T Prolongation in Human iPS Cell-Derived Cardiomyocytes

Huang, Chien-Jung, Callamaras, Nick, Germann, Ursula, Lechner, Sandra, Worley, Jennings

Journal:

Biophysical Journal

Année:

2012

Langue:

english

Fichier:

PDF, 42 KB

english, 2012

25

A case study to illustrate a potential challenge for preclinical hypotension risk assessment by cardiovascular telemetry in conscious, normotensive rats in advance of definitive large animal telemetry studies

Pannirselvam, Malar, Hodges, Donald, Prezioso, Joseph, Damian, Doris, Tanner, Kirk, Gao, Hong, Berlioz-Seux, Francoise, Germann, Ursula

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2013

Langue:

english

Fichier:

PDF, 68 KB

english, 2013

26

Isolation and Partial Nucleotide Sequence of the Laccase Gene from Neurospora crassa: Amino Acid Sequence Homology of the Protein to Human Ceruloplasmin

Ursula A. Germann and Konrad Lerch

Journal:

Proceedings of the National Academy of Sciences

Année:

1986

Langue:

english

Fichier:

PDF, 1.11 MB

english, 1986

27

The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor

Duffy, John P., Harrington, Edmund M., Salituro, Francesco G., Cochran, John E., Green, Jeremy, Gao, Huai, Bemis, Guy W., Evindar, Ghotas, Galullo, Vincent P., Ford, Pamella J., Germann, Ursula A., Wi

Journal:

ACS Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 1.84 MB

english, 2011

28

Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites

Chambers, Timothy C., Germann, Ursula A., Gottesman, Michael M., Pastan, Ira, Kuo, J. F., Ambudkar, Suresh V.

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 2.43 MB

english, 1995

29

Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors ‡

Aronov, Alex M., Baker, Christopher, Bemis, Guy W., Cao, Jingrong, Chen, Guanjing, Ford, Pamella J., Germann, Ursula A., Green, Jeremy, Hale, Michael R., Jacobs, Marc, Janetka, James W., Maltais, Fran

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 233 KB

english, 2007

30

Expression of the human multidrug transporter in insect cells by a recombinant baculovirus

Germann, Ursula A., Willingham, Mark C., Pastan, Ira, Gottesman, Michael M.

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 2.69 MB

english, 1990

31

A Novel Ranking System for Identifying Efficacious Anti-Influenza PB2 Inhibitors

Tsai, Alice W., McNeil, Colleen F., Leeman, Joshua R., Bennett, Hamilton B., Nti-Addae, Kwame, Huang, Cassey, Germann, Ursula A., Byrn, Randal A., Berlioz-Seux, Francoise, Rijnbrand, Rene, Clark, Mich

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2015

Langue:

english

Fichier:

PDF, 1.59 MB

english, 2015

32

Evaluating increased seizure potential by rhythmic bursts in electroencephalography (EEG) activity

Hodges, Donald, Foster, Kelly, Germann, Ursula, Sanders, Martin

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2014

Langue:

english

Fichier:

PDF, 49 KB

english, 2014

33

Fluorescent cellular indicators are extruded by the multidrug resistance protein

Homolya, L??szl??, Holl??, Zsolt, Germann, Ursula a., Pastan, Ira, Gottesman, Michael M., Sarkadi, Bal??zs

Journal:

Journal of Biological Chemistry

Année:

1993

Langue:

english

Fichier:

PDF, 545 KB

english, 1993

34

[Methods in Enzymology] ABC Transporters: Biochemical, Cellular, and Molecular Aspects Volume 292 || [31] Baculovirus-mediated expression of human multidrug resistance cDNA in insect cells and functional analysis of recombinant P-glycoprotein

Germann, Ursula A.

Année:

1998

Langue:

english

Fichier:

PDF, 1.04 MB

english, 1998

35

Survival of the Scandinavian total ankle replacement (STAR): results of ten to nineteen years follow-up

Frigg, Arno, Germann, Ursula, Huber, Martin, Horisberger, Monika

Journal:

International Orthopaedics

Année:

2017

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2017

36

Corneal Cross-Linking (CXL) for Therapy-Resistant Keratitis with Corneal Melting: It Is Never Too Late!

Ribeiro Reis, Ana Paula, Germann, Ursula Maria, della Volpe Waizel, Maria, Handtke, Juliane, Scholl, Hendrik Pn., Gatzioufas, Zisis

Journal:

Klinische Monatsblätter für Augenheilkunde

Année:

2020

Langue:

english

Fichier:

PDF, 168 KB

english, 2020

37

P4-506: ROLE OF P38Î± MAP KINASE IN AMYLOID-Î² DERIVED DIFFUSIBLE LIGAND (ADDL) INDUCED DENDRITIC SPINE LOSS IN HIPPOCAMPAL NEURONS

Amin, Ladan, Le, Nhat, Mercer, Robert C.C., Germann, Ursula, Alam, John, Harris, David A.

Journal:

Alzheimer's & Dementia

Année:

2019

Fichier:

PDF, 347 KB

2019

38

P38Î± MAPK SignalingâA Robust Therapeutic Target for Rab5-Mediated Neurodegenerative Disease

Germann, Ursula A., Alam, John J.

Journal:

International Journal of Molecular Sciences

Année:

2020

Fichier:

PDF, 844 KB

2020

39

EFFECTS OF P38Î± MAP KINASE INHIBITION ON THE NEURODEGENERATIVE PHENOTYPE OF THE TS2 DOWN SYNDROME MOUSE MODEL

Jiang, Ying, Stavrides, Philip, Darji, Sandipkumar, Yang, Dun-Sheng, Bleiwas, Cynthia, Smiley, John, Germann, Ursula, Alam, John, Nixon, Ralph

Journal:

Alzheimer's & Dementia

Année:

2019

Fichier:

PDF, 156 KB

2019